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Revitalise with Polynucleotides

Polynucleotides are a form of biostimulator derived from DNA segments that regenerate tissue, increasing collagen and elastin production. We are excited to introduce this innovative treatment at Sisu Clinic, which will result in healthier and more youthful-looking skin.

Polynucleotides treatment

Are Polynucleotides safe?

What is Polynucleotides about?

It might sound fishy, but this DNA structure, derived from salmon sperm, significantly enhances tissue regeneration. It boosts elastin and collagen production, decreases inflammation, improves tissue quality and density, and reduces pigmentation. The treatment is an injectable; we use a tiny needle to administer it just under the skin at specific points on the face and body. Polynucleotides require a series of treatments; to achieve the best results, we recommend 3-4 treatments spaced two weeks apart.
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1

Eyes

Improve skin hydration & circulation, which can lighten dark circles.

2

Cheeks

Result in plumper, more resilient skin + reduction in sagging.

3

Forehead

Softening the appearance of wrinkles & improving skin texture.

4

Neck and Decolletage

Improves skin laxity, crepey skin , fine lines and wrinkles.

5

Hands

Improves hydration and skin quality.

Polynucleotides At A Glance

Discover the key details about your treatment — from results to recovery.

Treatment Time

15–20 minutes

Back To Work

Can vary with every patient

Results Time

Long term results

Results see in

1 Month

Comfort

Comfortable

Side Effects

Bruising, temporary swelling

What it does...

Skin Not Treated
Skin Not Treated 1
Skin Not Treated 2
After Polynucleotides
After Polynucleotides 1
After Polynucleotides 2
After Hyaluronic Acid
After Hyaluronic Acid 1
After Hyaluronic Acid 2

In vivo study: Histological evaluation of tissue repair. Detections using Sirius red dye and polarised light

Short Term: Hydrating and volume-enhancing action similar to HA Reorganize into a hydrophilic three-dimensional gel that binds large amounts of water with an immediate volumising effect.

Long Term: It will promote fibroblast migration and growth, Enhance protein production, enhance extracellular matrix synthesis, reduce inflammation and promote angiogenesis.

Polynucleotides Benefits

Stimulates

Fibroblasts to Reduce Fine Lines & Wrinkles.

Remodels

Skin to Smooth Texture & Reduce Scars.

Repairs

Skin Cells to Calm Inflammation​ such as Rosacea.

Promotes

Bio-Regeneration to Increase Collagen.

Improves

Your Overall Skin Elasticity to Tighten Loose Skin​.

DNA Fractions

to Regenerate Skin Quality​ & Hydrates the Skin.

The Results

Eye AreaCheek AreaNeck AreaFace AreaEye Area

Testimonials powered By DNA

Hear from our satisfied clients from across the world and discover the life-changing impact of our treatments.

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Monica / London

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Lorna / London

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Ally / London

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Jasmine / London

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Naomi / London

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Your Questions

Answered By Your Doctor

Sisu Clinic has always led the way in providing a conscientious and ethical stance in the world of aesthetic medicine, we don’t do snake oil. What does that mean? If it doesn’t work, we don’t do it. That’s why we are happy to announce our Polynucleotide treatment is available across all of our Irish and UK clinics, we have not only had the treatment ourselves but our nearest and dearest have raved about it.

Given their powerful regenerative effects, polynucleotides can be injected into several areas, including the face, neck, and under-eye areas. One of the most popular areas to treat and one that gives insanely great results is the undereye area. Crepey, wrinkled under-eye skin, you’ve met your match!

Everyone can benefit from Polynucleotides! They enhance tissue quality, elasticity, and tone, resulting in soft, hydrated skin. Younger patients who aren't ready for dermal fillers appreciate the fresh-faced look, while older patients see improvements and can target specific issues like under-eye wrinkles. Polynucleotides, backed by science, effectively address these challenging areas, simplifying treatments for both patients and injectors alike.

Polynucleotides are not a one-hit-wonder; typically, patients need 3 to 4 treatments spaced 3-4 weeks apart, aligning with the skin's 30-day cell turnover cycle. Results begin to show about 2 weeks after the first treatment and improve with each subsequent session. Younger, skin-conscious patients generally require three cycles, while we recommend four cycles for older patients or those with specific problem areas.

At Sisu Clinic, every treatment begins with a personalized consultation. Are you suitable for Polynucleotides, or would dermal fillers or even surgery like blepharoplasty be more appropriate? If PDRN is right for you, the procedure is quick, taking about 5-10 minutes with a tiny needle to inject just under the skin. You may notice some swelling, particularly in the under-eye area, which typically subsides within 24-48 hours.

With any injectable treatment, swelling and bruising may occur. Your doctor will advise if you are likely to bruise post-treatment. This can take anywhere from 5-10 days to resolve, and you can cover the area with makeup 24 hours after the treatment. For under-eye treatments using polynucleotides, expect swelling for 24-48 hours. This area has relatively thin skin, so swelling may appear more pronounced compared to other areas.

At Sisu Clinic, we have teamed up with Mastelli, an Italian manufacturer leading the Polynucleotides revolution in Europe with their top-tier product, 'plinest.' At Sisu Clinic, we are very selective not only about the treatments we introduce but also about whom we team up with, and the team leading 'plinest' is world-class.

In aesthetic medicine, benefits are twofold: compliments on your appearance and the effective synergy between treatments. Combining Anti-Wrinkle with polynucleotides offers a powerful refresh or a red-carpet look. Adding a tissue modulator like Hyaluronic acid-based Profhilo enhances this effect even further. Our patients report that this trio often leads strangers to inquire about their skincare routines—truly a testament!

Polynucleotides Prices

for best results we recommend 3-4 treatments

Polynucleotides (1 Treatment)

€285

Polynucleotides (2 Treatments)

€500

Polynucleotides (3 Treatments)

€750

Polynucleotides (4 Treatments)

€999