Revitalise with Polynucleotide Injections Ireland

Polynucleotides (also known as PN or PDRN) are injectable bio-stimulators derived from purified salmon DNA. When injected into the skin, they activate your body's own fibroblasts to produce more collagen and elastin, improving skin quality, hydration and firmness from within. Unlike dermal fillers which add volume immediately, polynucleotides work by regenerating the skin over time — results build progressively with each session and continue improving after treatment is complete.

Polynucleotides can be used on the face, neck, under-eye area, décolletage and hands. The under-eye area is one of the most effective zones — the delicate skin there responds particularly well, with noticeable improvements in dark circles, hollowness and fine lines. The face and neck are also commonly treated for overall skin quality, texture and firmness.

Polynucleotides are suitable for most adults looking to improve skin quality, hydration and texture. They work especially well for people with early signs of ageing, dull or tired-looking skin, crepey skin around the eyes or neck, or anyone who wants to improve overall skin health rather than add volume. They are not recommended during pregnancy or breastfeeding. A consultation with one of our doctors will confirm suitability for your specific skin goals.

Polynucleotides are not a one-hit-wonder; typically, patients need 3 to 4 treatments spaced 3-4 weeks apart, aligning with the skin's 30-day cell turnover cycle. Results begin to show about 2 weeks after the first treatment and improve with each subsequent session. Younger, skin-conscious patients generally require three cycles, while we recommend four cycles for older patients or those with specific problem areas.

At Sisu Clinic, every polynucleotide treatment begins with a one-to-one consultation with a doctor to assess your skin and confirm suitability. If PDRN is right for you, the procedure is quick, taking about 5-10 minutes with a tiny needle to inject just under the skin. You may notice some swelling, particularly in the under-eye area, which typically subsides within 24-48 hours.

With any injectable treatment, swelling and bruising may occur. Your doctor will advise if you are likely to bruise post-treatment. This can take anywhere from 5-10 days to resolve, and you can cover the area with makeup 24 hours after the treatment. For under-eye treatments using polynucleotides, expect swelling for 24-48 hours. This area has relatively thin skin, so swelling may appear more pronounced compared to other areas.

Both are skin-quality treatments rather than volumising treatments, but they work differently. Profhilo uses ultra-pure hyaluronic acid to deliver intense hydration and trigger collagen and elastin production — ideal for skin laxity, dullness and early ageing. Polynucleotides use DNA fragments to regenerate skin at a cellular level — particularly effective for skin texture, fine lines and the delicate eye area. Neither is better than the other; they target different concerns and many patients benefit from both as part of a longer-term skin health plan. Your doctor will advise which is most appropriate for you.

Yes — polynucleotides work well alongside other treatments. Combining them with anti-wrinkle injections addresses both skin quality and expression lines for a more complete result. Pairing with Profhilo enhances hydration and collagen stimulation further. Many patients at Sisu Clinic use polynucleotides as part of a longer-term skin health plan rather than a one-off treatment.

Initial improvements in skin brightness and hydration are usually noticeable within 2 to 4 weeks of your first session. Results build progressively across the treatment course, with the most significant improvements in skin texture, firmness and quality visible around 6 to 8 weeks after your final session. Results typically last 6 to 12 months, with a maintenance session recommended to sustain them.

At Sisu Clinic, polynucleotide treatments are available as a single session or as a course for best results: one treatment €285, two treatments €500, three treatments €750, four treatments €999. A free consultation is included with all treatments.

Yes — the under-eye area is one of the most popular and effective treatment zones for polynucleotides. The thin, delicate skin there responds very well, with improvements in dark circles, hollowness and fine lines. Because polynucleotides stimulate the skin's own repair process rather than adding volume, they are particularly well-suited to this sensitive area where fillers require more caution.