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Youthful skin with

Polynucleotides are biostimulatory substances derived from purified DNA fragments. They act as messengers within the skin, stimulating the production of collagen and elastin – the building blocks that provide structure and elasticity. As we age, collagen and elastin production naturally decline, leading to wrinkles, fine lines, and loose skin.

Youthful glow

Increase in collagen


Increase in skin thickness

Polynucleotides have
regenerative powers.
Proven to increase
collagen by 43%
skin thickness by 53%.

What are Polynucleotides?

Polynucleotides, also known as polydeoxyribonucleotides, is the DNA structure derived from salmon sperm and has a huge regenerative effect on tissue allowing for increased production of elastin and collagen as well as increased tissue quality and density with the reduction of pigment. This revolutionary treatment is perfect for both rejuvenating mature skin and as a preventative treatment for younger skin, offering a versatile solution for all your skincare needs. Keep reading to discover the benefits, science behind this treatment, and what to expect during the procedure.

How do I choose a qualified provider for polynucleotide treatment?
Choosing a qualified provider for polynucleotide treatments is crucial to ensure safety and achieve the best results. At Sisu Clinic in the UK, we offer this treatment at four convenient locations: Richmond, Mayfair, Hampstead, and Belfast. As a doctor-led clinic, our expert providers are highly experienced in administering polynucleotide treatments.For a seamless experience, you can now book your appointment or free consultation directly through WhatsApp. Trust Sisu Clinic to deliver top-quality care and outstanding results for your skin rejuvenation needs.



Improve skin hydration & circulation, which can lighten dark circles.


Result in plumper, more resilient skin + reduction in sagging.



Softening the appearance of wrinkles & improving skin texture.


Neck and Decolletage

Improves skin laxity, crepey skin , fine lines and wrinkles.



Improves hydration and skin quality.


Benefits of PolynucleotidesBenefits of Polynucleotides

Polynucleotides At a Glance

Treatment time

15-20 mins


Can vary with every patient


Long term results


1 Month




Bruising, temporary swelling

What it does...

Skin Not Treated

Not Treated SkinTreated Skin

After Polynucleotides

Polynucleotides Injections AfterPolynucleotides Face

After Hyaluronic Acid

Hyaluronic Acid AfterCollagen production

In vivo study: Histological evaluation of tissue repair.
Detections using Sirius red dye and polarised light

Short Term: Hydrating and volume-enhancing action similar HA Reorganize into a hydrophilic three-dimensional gel that binds largeamounts of water with an immediate volumising effect.

Long Term: It will promote fibroblast migration and growth, Enhance protein production, enhance extra cellular matrix synthesis, reduceinflammation and promote angiogenesis

Polynucleotides Benefits

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Stimulates Fibroblasts to Reduce Fine Lines & Wrinkles

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DNA Fractions to Regenerate Skin Quality​ & Hydrates the Skin

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Repairs Skin Cells to Calm Inflammation​ such as Rosacea

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Stimulates the production of collagen and elastin

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Reduced appearance of dark circles and puffiness

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Natural-looking, subtle results with minimal downtime

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Long-lasting results (up to 6 to 12+ months)

The Results

Polynucleotides Eye Before and After
Before Treatment
After Treatment
Polynucleotides Cheek Before and After
Before Treatment
After Treatment
Polynucleotides Neck Before After - Sisu Clinic
Before Treatment
After Treatment
Polynucleotides Face Before & After Photos
Before Treatment
After Treatment
Polynucleotides eye Before & After Photos
Before Treatment
After Treatment

*Individual results and treatment regimens may vary.

Your Questions
Answered By Your Doctor

What is the recovery time after a polynucleotide treatment?

Recovery time is minimal, with most patients experiencing only mild redness and swelling that subside within a few days. Normal activities can usually be resumed immediately after the procedure, though it's advisable to follow any specific aftercare instructions provided by your healthcare provider.

How many polynucleotide treatments are needed for optimal results?

The number of treatments needed varies based on individual goals and skin conditions. Typically, a series of 3-4 treatments spaced a few weeks apart is recommended for optimal results. Maintenance sessions may be needed to sustain the effects.

Can polynucleotides be used in combination with other treatments?

Yes, polynucleotide treatments can be combined with other cosmetic procedures, such as hyaluronic acid dermal fillers, wrinkle relaxers to enhance overall results. It's important to consult with your healthcare provider to develop a customized treatment plan.

How long does it take to see results from polynucleotide treatments?

Results can vary, but many patients start to see improvements within a few days to a few weeks after the treatment. The full effects are typically visible after a series of treatments, spaced a few weeks apart.

Polynucleotides Under Eyes

The delicate under-eye area is particularly prone to wrinkles, puffiness, and dark circles. Polynucleotide injections can be a valuable tool for addressing these concerns. By stimulating collagen production and improving hydration, polynucleotides can help smooth out fine lines, reduce puffiness, and create a brighter, more youthful appearance under the eyes.

Polynucleotides vs Profhilo

Profhilo uses an innovative hyaluronic acid compound to boost collagen and elastin, deliver deep hydration, and restore your skin's radiance. Profhilo acts as a high-powered injectable moisturizer that works beneath the skin. It flows through the subcutaneous tissue and dermis to stimulate new collagen and elastin fibers, hydrating the skin from the inside out to smooth lines and brighten texture. Polynucleotides It might sound fishy, but this DNA structure, derived from salmon sperm, significantly enhances tissue regeneration. It boosts elastin and collagen production, decreases inflammation, improves tissue quality and density, and reduces pigmentation. The treatment is an injectable; we use a tiny needle to administer it just under the skin at specific points on the face and body. Polynucleotides vs Profhilo - Choosing between both When choosing between Profhilo and Polynucleotides, you will need to consider the following to help make your decision: Profhilo is excellent for deep hydration and overall skin rejuvenation, making it ideal for those looking to improve skin texture, smooth fine lines, and achieve a radiant glow. Polynucleotides, on the other hand, focus more on tissue regeneration, improving skin density, and reducing inflammation and pigmentation. Ultimately, the best choice depends on your specific skin needs and treatment goals. Consulting with your Sisu Doctor can provide personalised advice to help you make an informed decision. Book in for your free consultation today.

How do polynucleotides work?

Once injected into the targeted areas, polynucleotides trigger a cascade of cellular activity. They stimulate fibroblasts, the skin cells responsible for collagen and elastin production. Additionally, polynucleotides possess antioxidant properties, helping to combat free radical damage and improve overall skin health.

Are polynucleotides safe?

Polynucleotide treatments are generally considered safe when administered by a qualified healthcare professional. Common side effects include mild redness and swelling at the injection site, which usually resolve within a few days.

Polynucleotides Prices

for best results we recommend 3-4 treatments

Polynucleotides  (1 Treatment)


Polynucleotides (2 Treatment)


Polynucleotides (3 Treatment)


Polynucleotides (4 Treatment)